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These are the intrinsicclearance rate (the rate at which the liver metabolizes theparent compound, which can be measured in primary hepa-tocytes for the species of interest, including humans) andplasma protein binding (which can again be measured inspecies-specific plasma).

One of the better-studied andmost frequently detected Mdm2 isoform is Mdm2-B or Alt1.

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With the exception offluvoxamine, inhibition primarily involves CYP2D6, asshown in Table 24.5.

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